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| | Celiac Disease DNA and Antibody Testing
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Celiac
disease, also known as gluten-sensitive enteropathy or celiac sprue, is
a chronic, autoimmune disorder affecting approximately 1:100
individuals in the U.S. population. In genetically susceptible
individuals with HLA-DQ2 and/or HLA-DQ8, ingestion of gluten-containing
grains, especially wheat, causes inflammation of the small intestine
and leads to malabsorption. Long believed to be a rare gastrointestinal
disorder, celiac diesase is now known to be very common and to have a
wide range of both gastrointestinal and non-gastrointestinal symptoms.
In addition, many individuals have silent celiac disease with no overt
clinical symptoms, though damage to the gut mucosa may nevertheless be
occurring. This wide range of clinical presentation combined with
variable age of onset make celiac disease extremely difficult to
diagnose. Early diagnosis by antibody testing, DNA testing, and small
bowel biopsy is critical. Treatment by elimination of gluten from the
diet is essential for
preventing future tissue damage and avoiding increased risk of other autoimmune disorders in affected individuals.
| - Indications for Celiac Disease Testing
| | Relatives of individuals with celiac disease | | | Negative or equivocal antibody results (antiendomysial, tissue transglutaminase, or antigliadin) or intestinal biopsyresults in an individual with symptoms of celiac disease | | | Gastrointestinal symptoms including diarrhea, malabsorption, recurrent abdominal pain, abdominal distention,weight loss, hepatitis, and/or irritable bowel syndrome | | | Iron-deficient anemia | | | Persistently elevated transaminases | | | Dermatitis herpetiformis | | | Osteoporosis/osteopenia | | | Autoimmune disease including type-1 diabetes,thyroiditis, or Sjφgrens syndrome | | | Children with failure to thrive, short stature, delayed puberty, irritability,and/or attention-deficit disorder | | | Infertility and/or recurrent fetal loss | | | Recurrent aphtous stomatitis and/or dental enamelhypoplasia of permanent teeth | | | Migraine headaches, peripheralneuropathy, cerebellar ataxia, epilepsy, anxiety, and/or depression | | | Individuals with Down Syndrome,Turner syndrome, or Williams syndrome |
Please call Kimball Genetics for more information
| | | | Special Aspects of our Service:
| | Rapid turnaround time | | | Detailed reports with interpretation,
recommedations, and education | | | Genetic consultation by board-certified
genetic counselors and geneticists |
Celiac Disease Testing Services
| | Celiac Disease DNA Test
Specimen requirements: 5 ml whole blood in an EDTA (lavender top) tube (ambient) or cheek cell sample Turnaround time: 1 business day | | | Celiac Disease Antibody Panel
Tissue transglutaminase (tTG) IgAEndomysial antibody (EMA) IgA Gliadin antibody IgA, IgG
Total IgA
Specimen requirements: 4 ml serum (ambient)
Turnaround time: 2-3 business days | | | Combined Celiac Disease DNA Test and Celiac Disease Antibody Panel
Specimen requirements: 5 ml whole blood in an EDTA(lavender top) tube (ambient) or cheek cell sample and 4 ml serum (ambient)
Turnaround time: 2-3 days
Note: Any of these tests may also be ordered individually. |
| | | | | ©2005 Kimball Genetics Inc. (last updated 1/05) | |
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