The factor V Leiden mutation is the most common genetic risk factor for venous thrombosis, a serious health problem affecting approximately 1 in 1000 people and leading to 50,000 deaths annually in this country. This mutation is involved in 20-40% of venous thrombosis cases and is present in 5% of the general population. The Factor V Leiden DNA Test should be included in the evaluation of all patients with thrombosis or a family history of this condition. Venous thrombosis is multigenic, and up to a third of individuals affected with inherited thrombosis have two or more genetic defects. The Factor V Leiden mutation is also associated with multiple pregnancy loss and intrauterine fetal demise. Kimball Genetics provides the Factor V Leiden DNA Test separately, in combination with the Prothrombin (Factor II) DNA Test, or as part of panels including coagulation tests for other inherited hypercoagulability disorders.
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- Indications for Factor V Leiden DNA Testing:
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Factor V Leiden/Inherited Hypercoagulability Testing Services:
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Factor V Leiden DNA Test
Specimen requirements: 5 ml whole blood in an EDTA tube (lavender top)
Turnaround time: 1 business day
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Combined Factor V Leiden/Prothrombin (Factor II) DNA Test
Specimen requirements: 5 ml whole blood in an EDTA tube (lavender top)
Turnaround time: 1 business day
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Inherited Hypercoagulability Panels
Panel A - for patients not on Coumadin therapy
Factor V Leiden DNA Test, Prothrombin (Factor II) DNA Test, Antithrombin Activity, Protein C Activity, Protein S Activity
Panel B - for patients on Coumadin therapy
Factor V Leiden DNA Test, Prothrombin (Factor II) DNA Test, Antithrombin Activity, Protein C Antigen, Protein S Antigen, Protein C/Factor IX Antigen Ratio, and Protein S Anitgen/Factor IX Antigen Ratio
Specimen requirements: 5 ml whole blood in an EDTA tube (lavender top) and 3 ml frozen citrated plasma in 1 ml aliquots
Turnaround time:
3-4 days (Panel A)
4-6 days (Panel B)
Note: Any of these tests may also be ordered individually.
Please call Kimball Genetics for more information.
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